The end of days, according to the Mayan calendar.  Other's have pegged   2012 as the end for various reasons.

The US economy continues to decline.

War rages in the Middle East

Antibiotic resistant diseases continue to appear, and new diseased are brought in across porous national borders

The governments continue to crack down amongst increasing unrest

Food prices soar as inflation reaches epic proportions.

Allegations of voting fraud in the US increase.

By 2010, the results of election in the US are reported by often disbelieved

An isolated president attempts to address a 20% unemployment rate with   a massive influx of government spending.

by 2011, major bank failures are a daily occurance.  Unemployment   reaches 40%. Food riots occur in several large US cities.

Marshal law is declared

In early 2012, the first terrorist nuclear device is detonated in Tel Aviv.

Israel responds by dropping nuclear weapons on Mecca and Medina.

The entire middle east explodes into war.

Oil prices reach $20 per gallon

Food prices triple as fertilizer and pesticide prices skyrocket

Famine becomes an issue in the United States. Mass famines in the third world are starving billions.

India and China have several border clashes.

In Africa, a new, highly contagious form of viral hemorrhagic fever appears.  It begins spreading rapidly across Africa and Asia.

The November presidential elections are to even too call, and there is   widespread evidence of vote count fraud.

Several states threaten succession, and the country is split in support of two presidents.

The Red Plague gains ground in South America and the first 'official'   cases appear in the US in december.

Pharmaceutical companies are nationalized and the CDC begin to work feverishly to develop a cure or vaccine for the black death of the 21st century. The red Plague spreads so quickly, that nucear weapons are used on infection sites in the hope of stopping the disease.

Volunteers are required.  Some are prisoners or those held on various   charges of sedition and other crimes new to the current Regime.

Others are enticed by offers of gold 'new dollars' and other rewards.    The money offered to these human guineas pigs is enough to start over,  to have a home and buy the increasingly scarce and expensive food.

Welcome guinea pigs....